I haven't used the Fast Light Toolkit (FLTK) for anything serious yet, but I'm a fan of the C++ GUI toolkit that's pretty simple to learn and (in my experience) reliable even across updates. When I found out that there was a desktop environment built with FLTK, I was eager to try it—and I was quickly glad I did. The Equinox Desktop Environment (EDE) is a fast and simple desktop written in C++ and FLTK for Unix desktops.
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